Genetic testing in Ukraine

Preimplantation genetic diagnosis/screening (PGD / PGS) is a diagnostic procedure used in the treatment of IVF when there is a risk of developing genetic disorders in the fetus. Also, the ASG makes it possible to determine the sex of the child to be born.
The ICSI Clinic was one of the first in Ukraine to introduce an ultra-precise method of preimplantation genetic screening – the NGS method, which allows detecting any chromosomal aberration or genetic disease caused by a known gene mutation. The distinctive feature of the NGS method is its high accuracy and reliability in detecting genetic anomalies.
NGS (Next Generation Sequencing) significantly enhances the efficiency of IVF, as even before an embryo is implanted, all known chromosomal pathologies can be identified. In 50 percent of cases, pregnancy is interrupted under the IVF program.

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How we do NGS diagnostics

On the fifth day after fertilization, the embryo begins to differentiate into the intracellular mass that forms the basis of the fetus, and into the cells of the outer layer, the trophectoderm, which will participate in implanting the embryo into the uterine cavity and form the fetal part of the placenta.

To analyze the NGS, we take several trophectoderm cells using precision tools. The ability to damage the embryo at this point is extremely limited. Cells taken for analysis will be tested by NGS for genetic or chromosomal anomalies. The process is very precise and allows to detect of any genetic disease associated with any known genetic disease. Results of NGS diagnostics with 99.9% accuracy.

Pending the results of the analysis, embryos are frozen by vitrification, and diagnosed embryos must be transported in a cryo cycle to prevent the risk of hyperstimulation. It also increases the efficiency of implantation of embryos into the uterine cavity.

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PGA / ASG is strongly encouraged to:

If the mother is over 35 years of age;
Repeated miscarriages;
If there was a pregnancy with chromosomal abnormalities of the fetus in the past;
In the case of several unsuccessful IVF attempts;
in cases where one of the parents has chromosomal translocations.

PGD/PGS/NGS analysis allows choosing a chromosomally normal embryo before implantation. Besides, the ASG makes it possible to determine the sex of the child to be born.

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FAQ

What are the risks to pregnancy and the child during genetic testing?

Preimplantation genetic testing does not pose any threat to pregnancy, as it is carried out before pregnancy. Trophectoderm cells are taken for the test. The trophectoderm cell biopsy procedure does not pose any threat to the embryo. Micromanipulation is as safe as possible.

Why is genetic testing important?

Chromosomal abnormalities are one of the most common causes of pregnancy failure or early termination. Preimplantation genetic testing prevents the transfer of embryos with chromosomal abnormalities.

Can the results of genetic testing be wrong?

The probability of error is very low, the accuracy of NGS testing is 99.9%.

What are the disadvantages of genetic testing?

PGT requires cryopreservation of the embryo and subsequent cryotransfer. Testing and the use of a cryoprogramme increases the cost of the IVF programme and extends its duration, but the success rate also increases.

Does genetic testing show autism and Down syndrome?

One of the types of genetic testing, PGT-A, can detect chromosomal aneuploidies, which include Down syndrome. Since the genetic nature of autism is complex and not fully understood, there is no 100% accurate genetic test for this disease yet. However, it is possible to identify chromosomal abnormalities and genetic mutations that are likely to be associated with autism.